Most people taking popular drugs like Ozempic and Wegovy to lose weight have shed significant pounds. But obesity experts say that roughly 20% of patients — as many as 1 in 5 — may not see robust results with the new medications. The response to the drugs varies from person to person and can depend on genetics, hormones and differences in how the brain regulates energy. Undiagnosed medical conditions and some drugs can prevent weight loss. Experts say it can take experimentation to help so-called nonresponders find results.
