by Yongfeng Bai, Siwei Wang, Wenkai Xu, Yuanyuan Weng, Shengmei Zhu, Hao Sheng, Jin Zhu, Feng Zhang
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by Neil L. Andrew, Phil Bright, Luis de la Rua, Shwu Jiau Teoh, Mathew Vickers
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by Maha Fezza, Mayssam Moussa, Rita Aoun, Rita Haber, George Hilal
Dickkopf-1 (DKK1), an inhibitor of the most frequently impaired signaling pathway in hepatocellular carcinoma (HCC), the Wnt/beta-catenin pathway, seems to fulfill contradictory functions in the process of tumorigenesis, acting either as an oncogenic promoter of metastasis or as a tumor suppressor. Elevated serum levels of DKK1 have been reported in HCC; however, little is known about its functional significance. In the current study... Читать дальше...
by Benjamin Faist, Fabian Schlott, Christian Stemberger, Kevin M. Dennehy, Angela Krackhardt, Mareike Verbeek, Götz U. Grigoleit, Matthias Schiemann, Dieter Hoffmann, Andrea Dick, Klaus Martin, Martin Hildebrandt, Dirk H. Busch, Michael Neuenhahn
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by Pablo Arroyo, Bryan S. Ho, Lillian Sau, Scott T. Kelley, Varykina G. Thackray
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by Suresh J. Gawande, Sivalingam Anandhan, Ashish Ingle, Praveen Roylawar, Kiran Khandagale, Tushar Gawai, Alana Jacobson, Ramasamy Asokan, Major Singh
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by Hannes Hagström, Linnea Widman, Erik von Seth
BackgroundAlcohol is a major risk factor for liver cirrhosis. Recently, it was proposed that colder climate might causally lead to increased consumption of alcohol.
MethodsWe performed an ecologic study, using monthly updated data on mean temperature, sunlight hours and alcohol consumption from ten regions in Sweden, using publicly available data. A generalised additive model, adjusted for region, was applied to examine the association... Читать дальше...
by Octavio Mesner, Alex Davis, Elizabeth Casman, Hyagriv Simhan, Cosma Shalizi, Lauren Keenan-Devlin, Ann Borders, Tamar Krishnamurti
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by Pascal Detampel, Anutosh Ganguly, Sara Tehranian, Francis Green, Santiswarup Singha, Pere Santamaria, Ayodeji A. Jeje, Clifford S. Cho, Björn Petri, Matthias W. Amrein
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by Fabrizio Carbone, Leonardo Bruno, Gaetano Perrotta, Maria B. Bitonti, Innocenzo Muzzalupo, Adriana Chiappetta
by Elena Garonna, Kathleen M. Botham, Graeme M. Birdsey, Anna M. Randi, Ruben R. Gonzalez-Perez, Caroline P. D. Wheeler-Jones
by Wesley LaBarge, Saidulu Mattapally, Ramaswamy Kannappan, Vladimir G. Fast, Daniëlle Pretorius, Joel L. Berry, Jianyi Zhang
by Luchuo Engelbert Bain, Marjolein B. M. Zweekhorst, Mary Amoakoh-Coleman, Seda Muftugil-Yalcin, Ibukun-Oluwa Omolade Abejirinde, Renaud Becquet, Tjard de Cock Buning
by Sarah K. Buddenborg, Bishoy Kamel, Ben Hanelt, Lijing Bu, Si-Ming Zhang, Gerald M. Mkoji, Eric S. Loker
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by Nicholas J. Clark, Irenee Umulisa, Eugene Ruberanziza, Kei Owada, Daniel G. Colley, Giuseppina Ortu, Carl H. Campbell Jr, Emmanuel Ruzindana, Warren Lancaster, Jean Bosco Mbonigaba, Aimable Mbituyumuremyi, Alan Fenwick, Ricardo J. Soares Magalhaes, Innocent Turate
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by Toni Whistler, Ornuma Sangwichian, Possawat Jorakate, Pongpun Sawatwong, Uraiwan Surin, Barameht Piralam, Somsak Thamthitiwat, Chidchanok Promkong, Leonard Peruski
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by Hannah Kuper, Maria Elisabeth Lopes Moreira, Thália Velho Barreto de Araújo, Sandra Valongueiro, Silke Fernandes, Marcia Pinto, Tereza Maciel Lyra
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by Vikram Patel, Pattie Pramila Gonsalves
In September’s Editorial, Vikram Patel and Pattie Gonsalves discuss suicide prevention, the focus of World Mental Health Day, 2019.
by Simone Mumbauer, Justine Pascual, Irina Kolotuev, Fisun Hamaratoglu
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by Sol Fereres, Ryo Hatori, Makiko Hatori, Thomas B. Kornberg
Communication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor-associated cells, we analyzed EGFR and RET Drosophila tumor models and tested several genetic loss-of-function conditions that impair cytoneme-mediated signaling. Neuroglian, capricious... Читать дальше...
by Matthew L. Bendall, Miguel de Mulder, Luis Pedro Iñiguez, Aarón Lecanda-Sánchez, Marcos Pérez-Losada, Mario A. Ostrowski, R. Brad Jones, Lubbertus C. F. Mulder, Gustavo Reyes-Terán, Keith A. Crandall, Christopher E. Ormsby, Douglas F. Nixon
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by Ivan Jurić, Julian M. Hibberd, Mike Blatt, Nigel J. Burroughs
Achieving global food security for the estimated 9 billion people by 2050 is a major scientific challenge. Crop productivity is fundamentally restricted by the rate of fixation of atmospheric carbon. The dedicated enzyme, RubisCO, has a low turnover and poor specificity for CO2. This limitation of C3 photosynthesis (the basic carbon-assimilation pathway present in all plants) is alleviated in some lineages by use of carbon-concentrating-mechanisms... Читать дальше...
by Olivier Collier, Véronique Stoven, Jean-Philippe Vert
Cancer driver genes, i.e., oncogenes and tumor suppressor genes, are involved in the acquisition of important functions in tumors, providing a selective growth advantage, allowing uncontrolled proliferation and avoiding apoptosis. It is therefore important to identify these driver genes, both for the fundamental understanding of cancer and to help finding new therapeutic targets or biomarkers. Although the most frequently mutated driver genes have been identified... Читать дальше...
by Lauren Rodriguez, Mark Voorhies, Sarah Gilmore, Sinem Beyhan, Anthony Myint, Anita Sil
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